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Acne |
Low-Intensity
Indocyanine-Green Laser Phototherapy Of Acne
Vulgaris: Pilot Study.
Genina EA, Bashkatov AN, Simonenko GV, Odoevskaya
OD, Tuchin VV, Altshuler
GB.Saratov State University, Optics Department,
Astrakhanskaya 83, Saratov 410026, Russia.
Near infrared (NIR) diode laser low-intensity (soft)
phototherapy with the topical
application of indocyanine green (ICG) has been
suggested for treatment of acne
vulgaris. Twelve volunteers with acne lesions on
their faces and/or backs were enrolled in the
experiment. Skin areas of the subjects that were 4x5
cm(2) were stained with ICG solution for 5 min
before laser irradiation (803 nm) at a power density
up to 50 mW/cm(2) for 5 to 10 min.
For 75% of the subjects, a single treatment was
provided and for the other 25%, eight sequential
treatments over a period of a month were carried
out. Observations a month after the completion of
the treatment showed that only the multiple
treatments with a combination of ICG and NIR
irradiation reduced inflammation and improved the
state of the skin for a month without any side
effects. A month after treatment, the improvement
was about 80% for the group receiving multiple
treatments. Single treatments did not have a
prolonged effect.
Light Therapy In
The Treatment Of Acne Vulgaris
Elman M, Lebzelter J.
Dermatology and Lasers Clinic, Tel Aviv Msq,
Caesarea, Israel.
BACKGROUND : Over the past decade, lasers and
light-based systems have become a common modality to
treat a wide variety of skin-related conditions,
including acne vulgaris. In spite of the various
oral and topical treatments available for the
treatment of acne, many patients fail to respond
adequately or may develop side effects. Therefore,
there is a growing demand by patients for a fast,
safe, and side-effect-free novel therapy.
OBJECTIVES : To address the role of light therapy in
the armamentarium of treatments for acne vulgaris,
to discuss photobiology aspects and biomedical
optics, to review current technologies of
laser/light-based devices, to review the clinical
experience and results, and to outline clinical
guidelines and treatment considerations.
RESULTS : Clinical trials show that 85% of the
patients demonstrate a significant quantitative
reduction in at least 50% of the lesions after four
biweekly treatments. In approximately 20% of the
cases, acne eradication may reach 90%. At 3 months
after the last treatment, clearance is approximately
70% to 80%. The nonrespondent rate is 15% to 20%.
CONCLUSIONS : Laser and light-based therapy is a
safe and effective modality for the treatment of
mild to moderate inflammatory acne vulgaris.
Amelioration of acne by light therapy, although
comparable to the effects of oral antibiotics,
offers faster resolution and fewer side effects and
leads to patient satisfaction. |
