Influence Of Low Dose Laser Therapy On Endothelial Function In Patients With Cad
S. Belousov, E. Galperin, E. Smetova
The purpose of this study was the evaluation of arterial relaxation ability in 15 patients with CAD before and after the course of infrared laser therapy. 18 controls (healthy men).
With high-resolution ultrasound and impulse wave doppler we measured the increasing of volumic velocity flow (%) of the arteria poplitea at rest and during reactive hiperaemia (with increased flow causing endothelium-dependent dilatation). In controls flow-mediated mean dilatation was normal. Endothelial dysfunction is present in majority of patients with CAD, flow-mediated dilatation was much reduced of absent. Course of infrared laser therapy was benefit to restore endothelial function in patients with CAD.
Vopr Kurortol Fizioter Lech Fiz Kult. 2003 Jul-Aug;(4):10-3.

Efficacy Of Laser Therapy In Patients With Ischemic Heart Disease
Vasil'ev AP, Strel'tsova NN, Senatorov IuN.- Article in Russian
Modification of erythrocytic membrane and the trend in clinicofunctional indices were
studied in 93 patients with angina of effort (FC i-IV) in the course of treatment with laser radiation (group 1) and imitation of laser radiation (group 2). In patients of group 1 the treatment resulted in stabilization of cell membrane accompanied with positive
cardiodynamic changes.
Klin Med (Mosk). 2002;80(4):31-3.

Diagnostic Implications Of Changed Red Cell Count In Low-Intensity Laser
Radiation Of Blood In Elderly Patients With Coronary Heart Disease
Simonenko VB, Siuch NI, Vokuev IA.- Article in Russian
Intravenous laser therapy in combination with medication was conducted in 41 elderly patients with coronary heart disease (633 nm, 1 mW, 124 mW/cm2). The study of qualitative and quantitative (osmotic resistance) erythrocyte indices of blood demonstrated the change of erythrocyte number in circulating blood by the third laser procedure. Frequency of these changes correlated with duration of the treatment course. Intravenous laser therapy had a wider spectrum
of effects on erythrocyte number than medication. Changes in erythrocyte number in the peripheral blood upon intravenous laser radiation reflects efficiency of treatment of coronary heart disease patients.
Vopr Kurortol Fizioter Lech Fiz Kult. 2001 Nov-Dec;(6):10-3.

Laser Irradiation In The Treatment Of Ischemic Heart Disease
Vasil'ev AP, Strel'tsova NN, Senatorov IuN.- Article in Russian
Cardiodynamic changes due to beta-blocker carvedilol and low-intensity infrared laser
radiation were compared in 115 patients with ischemic heart disease (IHD). The
comparison has shown a similar positive effect on heart contractility and diastolic
function. This gave arguments for feasibility of laser beam usage as a neurohormonal
modulator in IHD patients to reduce cardiac remodulation and prevent cardiac failure.
Vopr Kurortol Fizioter Lech Fiz Kult. 2003 May-Jun;(3):22-5.

Antioxidant Action And Therapeutic Efficacy Of Laser Irradiation Of Blood In Patients With Ischemic Heart Disease
Volotovskaia AV, Ulashchik VS, Filipovich VN.- Article in Russian
Laser irradiation in therapeutic doses (gamma = 632.8 nm, 14 mW) has an antioxidant effect in blood irradiation in vitro as shown by activation of superoxide dismutase (SOD) which is a key enzyme of the antioxidant system (AOS) and suppression of lipid peroxidation. Adjuvant supravascular He-Ne laser irradiation of blood in combined therapy of 82 patients with ischemic heart disease (IHD) produces a positive trend in the clinical picture, hemostasis, lipid metabolism, blood SOD activity. Thereby, this method of laser hemotherapy is recommended for use in IHD patients. The dependence of the treatment results on the initial blood AOS necessitates consideration of AOS state in
deciding on laser therapy in this group of patients.
Vopr Kurortol Fizioter Lech Fiz Kult. 2002 Jul-Aug;(4):9-11.

Use Of Infrared Laser Therapy In Patients With Ischemic Heart Disease Associated With Diabetes Mellitus Type 2 In Health Resort
Zin'kovskaia TM, Zavrazhnykh LA, Golubev AD.- Article in Russian
Infrared laser therapy (300 Hz) combined with balneotherapy and patients' education is more effective than standard sanatorium rehabilitation in patients with ischemic heart disease associated with diabetes mellitus type 2. 81.8% patients showed good response manifesting in less frequent anginal attacks, episodes of pain and painless ischemia and lower doses of antianginal drugs. Systolic and diastolic arterial pressure lowered by 18 and 10 mm Hg on the average, respectively. Multimodality rehabilitation of IHD patients with type 2 diabetes mellitus improves hemostasis, carbohydrate and lipid metabolism.
Coronary circulation response lasted for 24 weeks.

EFFECTS OF LASER THERAPY ON VENTRICULAR AND SUPRAVENTRICULAR
EXTRASYSTOLES IN PATIENTS WITH ANGINA PECTORIS OF 1-3 FUNCTIONAL CLASSES
V.A. Lyusov, K.G. Khutchumova, Y.N. Fedullaev
The Russian Medical State University, Moscow, Russia
The aim of the present investigation is to study the effect of low level laser on
extrasystoles. The amount of citrasystoles is registered before treatment and on the 10th day after the therapy. 64 patients with angina pectoris underwent laser therapy. We registered patients with more than 200 supraventricular extrasystoles and with more than 100 ventricular extrasystoles before our therapy. The treatment was carried out the keep of GaAs laser (890 nm) with pulse regime. The region of projection of carotide sinuses and heart were irradiated with pulse repetition rate 150 - 300 Hz with expositions 20 min. The amount of extrasystoles was counted by Holter monitor device. Laser therapy lessened supraventricular citrasystoles from 308,4±29,6 to 134,6±21,8 (p<0,001)
and ventricular extrasystoles - from 182,1±31,3 to 41,5±16,3 (p<0,05) in patients with 1-3 functional class. We observed a decreased number of extrasystoles in 2 FC by 39,9 percent and by 13,7 percent, respectively. On patients with 3 FC - by 38,7 percent (p<0,001) and by 13,3 percent (p<0,05), respectively. This effect could still be observed after two months after the treatment. The results showed, that laser therapy lessened extrasystoles and that it can be applied as an effective means when treating ventricular and supraventricular extrasystoles in patients with angina pectoris 1-3 FC.

The Effectiveness And Influence On Rheological Blood Features And Endothelian Vessels Function Of Infrared Laser Therapy In Patients With Angina Pectoris
T.M. Zenkovskaya, O.A. Matronchick, F.A. Khairullina, A.D. Kats
Hospital of War Invalids, Perm State Medical Academy, Russia
One can observe the impairment of endothelian vessels function (EVF) and rheological blood features (RhBF) in patients with various forms of ischemic heart disease. The task of this investigation is the study of infrared laser therapy (IRLT) influence to RhBF, EVF; the dependence of treatment effectiveness from above stated functions. 58 patients with stable angina pectoris III and IV functional class where under supervision. IRLT was performed by means of USOR and ASOR-2K apparatus with rate 300 Hz, the procedure lasted 10 minutes and it was given 10 times. To evaluate treatment effectiveness and its dependence on RhBF we have studied erythrocyte aggregation (EA), we have counted erythrocyte aggregation coefficient (EAC), the erythrocyte flowing (HF), it was marked by the index of flowing (IHF), spontaneous thrombocytcs aggregation (SThA) before and after IRLT and capillary fragility test (CFT). Before IRLT EAC was 0.78±0.04, after it was 0.89±0.06 (p<0.05), standard - 1.0. Before IRLT 1EF was 80,44±0.96%, after it was 90.47±0.91% (p<0.05). SThA was higher standard in the majority of patients before therapy. It decreased after the therapy. After CFT SThA reduced in patients given IRLT (25.81±1.50%, 20.39±0.91% and 17.51±0.11%). The lowering of SThA did not occur in patients treated only with medical preparations. The IRLT was effective in 91.7%. The effect of therapy was higher in patients with reliable lowering of EA, SThA, increased IEF. Therefore the IRLT is highly effective method of
angina pectoris treatment and improves rheological properties of blood and endothelium vessels function.

Results Of 10-Year Use Of Low Intensity Laser Therapy And Conventional Treatment Of Patients With Stenocardia
G.W. Babushkina, I.M. Korochkin, A.V. Kartelishev
Bashkir Medical University, Ufa, Russian State Medical University, Moscow, RF
The improvement of treatment and rehabilitation of patients with CHD remains to be a
vital problem in cardiology, as morbidity, disability and mortality rates keep steadily
growing. However, insufficient efficacy of therapeutic methods, the development of
retraction to antianginal drugs, their intolerance make medical men search for the new methods of CHD treatment, nonmedicamental ones inclusive. This paper presents the results of 10-year observation over two groups of patients with CHD (the main and control). 280 patients, who underwent a course of laser therapy (LT), have been included in the main group (A), the control (B) 155 patients have been treated conventionally.
Prospective observation demonstrated new cases of acute myocardial infarction (AMI), mortality from CHD as well. There were 26 cases of AMI (II, 9 cases per 1000
population a year) in the main group, 27 AMI cases (27.4 per 1000 people a year) in the control over the observation period. The analysis of the acute attack and AMI
development incidence in II - IV functional class (FC) stenocardia patients for 5 years
before and after LT annual course demonstrated that the patients who underwent the
repeated antirelapsing course of low intensity LT during remission showed reliable
advantage (p<0,01 to p<0,05) of the method used as well as its prophylactic effect to
prevent CHD progressing which was confirmed by biochemical blood analysis (lipid
metabolism and rheologic properties). During the observation period there were 54
deaths: 8,9% in the main and 18,7% in the control group. CHD was the main cause of death in both groups which made 84% and 89.6% respectively of all death causes.
Mortality rate was 17,4 and 32,6 respectively per 1000 population a year (p<0,01). On the whole, prospective analysis of the obtained data showed that LT course is directly dependent on its type and frequency of repeated courses and enables to prolong therapeutic remission of CHD by 2,5 times on the average. Thus, low intensity LT is a method of choice for patients suffering from different forms of angina pectoris and is carried out either in combination with conventional drug therapy or alone.

Intravenous A Laser Irradiation Of Blood In Complex Rehabilitation Of The Patients With Ischemic Heart Disease In The Senior Age Groups
Y.M. Kazakov, L.A. Zvyaginceva, et al.
Ukrainian medical stomatological academy, Poltava, Ukraine
The problem of rehabilitation of the ischemic heart disease (IHD) patients remains essential. Use of physical methods of treatment of the given category of the patients in connection with numerous lacks in drug treatment (collateral action, decrease of tolerance with long treatment, sometimes their inaccessibility for continuous treatment) gets the increasing distribution. 32 IHD patients are surveyed, from them 6 IHD patients had a combination with arterial hypertension.
Average age explore patients - 66±4 years. On a background of a dietary nutrition and basic treatment with nitrates have carried out an irradiation of blood by the helium-neon laser through light-guide in cubital vein with capacity 1,5 mW, exposition - 30 minutes once per day within ten days. As a result of complex treatment there has come an improvement of a common condition of the patients was noted, normalization of rheological parameters of blood. Thus, intravenous laser blood irradiation can be used for the treatment of patients with IHD in stage of the ambulatory rehabilitation, including the patients of the senior age groups.

The Application Of Low-Intensity Laser Radiation For The Treatment Of Infarctional Patients With Early Angina Pectoris Refractering To The Drug Therapy
Y.L.Gabinsky, Y.R. Yakovlev, S.V. Yakovleva
Yekaterinburg Infarction Centre, Yekaterinburg, Russia
The results of treatment by low-intensity laser radiation of blood are given with taking
into account of individual sensitivity in process of laser therapy. 600 patients with
myocardial infarction and early angina pectoris (500 patients simultaneously with drug therapy were given laser therapy, 100 patients were given only drug therapy) were examined. The selecting of dose of laser radiation was based on refraction index of blood plasma in the field of laser radiation in vitro. Before the starting of laser therapy, in the middle of the course and at the end of it the state of health was estimated according to the theory of stress by Selie. In the group of patients, receiving laser therapy, the pronounced positive clinical effect has been registered. According to our data this effect reflects the changing of blood coagulation.

Efficiency Of Intravascular Blood Irradiation With He-Ne Laser In Patients With Stable Effort Angina Pectoris Depending On Functional Class
A.I. Koryakov Sverdlovsk Regional Clinical Psychoneurological Hospital of the Disabled Soldiers, Yekaterinburg, Russia
The aim of this study was the comparison of antianginal effect of intravascular He-Ne
laser irradiation of blood (ILIB) in patients with different functional classes of angina
pectoris. The tolerance to exercise was studied in 44 men with stable angina, functional classes I-II have been registered in 20 patients, functional classes III-IV - in 24 patients.
Four veloergometer tests both before and after the course of invasive treatment were
performed for every patient under circumstances of total abolition drugs. All 44 patients were randomized by the blind method into ILIB and placebo groups. Nine men with the slight angina pectoris and 15 patients with the painful angina pectoris were subjected to 6 ILIB seances, the total course dose was 21,6±0.8 J. We used the He-Ne laser radiation (wavelength 632,8 nm) from the three-wave laser therapy device "Adept", the light power in the end of intravenous light-guide was from I to 2 mW. Other 11 patients with angina functional classes I-II and 9 patients with angina pectoris functional classes III-IV received the placebo course of six invasive procedures. The effect of ILIB was calculated as a difference of increases in the mean-sample maximum workload between the laser therapy group and the placebo group. In patients with severe angina ILIB increased the exercise power reached on veloergometer on the average by 7,3±3,2 W (t = 5,26; p = 0).
In contrast, in patients with the high tolerance to exercise ILIB did not significantly affect this parameter. We obtained the great difference in effects of ILIB in patients with the serious angina pectoris and the mild stenocardia (t = 2,41, p = 0,03), Thus, efficacy of the invasive blood irradiation with He-Ne laser in patients with stable effort angina pectoris depended on the initial tolerance to exercise.

Influence Of Intravenous Blood Irradiation With He-Ne Laser On The Antianginal Effect Of Nitroglycerin In Patients With Stable Effort Angina Pectoris
A.I. Koryakov, N.N. Koryakova, A.I. Iofin
Sverdlovsk Regional Clinical Psychoneurological Hospital of the Disabled Soldiers,
Yekaterinburg, Russia
We reported about the significant antianginal effect of intravenous He-Ne laser
irradiation of blood (ILIB) in patients with serious stable effort angina functional classes 3-4. The goal of this work was to investigate an action of ILIB on an increase of the tolerance to exercise after the sublingual taking nitroglycerin in dose 0.5 mg in patients with stenocardia. We observed 27 men with stable effort angina functional classes II-IV.
All patients were subjected two conjugate loading tests on veloergometer with
nitroglycerin both before and after of the seven-day treatment. The antianginal effect of nitroglycerin was calculated as the magnitude of the increase maximum workload after taking nitroglycerin in comparison with the initial level of the maximum exercise power.
Patients were divided randomly into main and control groups (17 and 10 men
accordingly). Patients from the master group were subjected to six seances of ILIB.
Power at the light-guide end was 1-2 mW, the accumulated dose was 21.6±0.8 J. The control group received the course of 6 invasive 45-minute placebo procedures that outwardly were like seances of ILIB. Both the intravascular laser treatment and its imitation were performed with three-wave laser therapy device "Adept". In all patients invasive procedures were combined with antianginal medication treatment that was abolished 1 -2 days before loading tests. Although after the treatment the increase of antianginal effect of nitroglycerin was not statistically significant in both groups, nevertheless after ILIB the rise of nitroglycerin's effect was more by 63 per cent as compared with placebo (p> 0.9). Thus, ILIB not only increases tolerance to exercise in patients with severe stable effort angina, but also it is not decreases the antianginal effect of nitroglycerin.
Vopr Kurortol Fizioter Lech Fiz Kult. 2002 Jul-Aug;(4):9-11.

Use Of Infrared Laser Therapy In Patients With Ischemic Heart Disease Associated With Diabetes Mellitus Type 2 In Health Resort
Zin'kovskaia TM, Zavrazhnykh LA, Golubev AD. - Article in Russian
Infrared laser therapy (300 Hz) combined with balneotherapy and patients' education is more effective than standard sanatorium rehabilitation in patients with ischemic heart disease associated with diabetes mellitus type 2. 81.8% patients showed good response manifesting in less frequent anginal attacks, episodes of pain and painless ischemia and lower doses of antianginal drugs. Systolic and diastolic arterial pressure lowered by 18 and 10 mm Hg on the average, respectively. Multimodality rehabilitation of IHD patients with type 2 diabetes mellitus improves hemostasis, carbohydrate and lipid metabolism.
Coronary circulation response lasted for 24 weeks.
Sov Med. 1990;(3):12-5.

Helium-Neon Laser Therapy In The Combined Treatment Of Unstable Stenocardia
Korochkin IM, Kapustina GM, Babenko EV, Zhuravleva NIu.- Article in Russian
He-Ne laser therapy included in complex of therapeutic methods for patients with
unstable angina pectoris is a highly effective treatment modality; it helps essentially
reduce the risk of acute myocardial infarction in these patients. Clinical efficacy of laser therapy is confirmed by its favorable action on hemostasis plasma factors, consisting in reduction of fibrinogen level, normalization of antithrombin-III (AT-III), decrease of the level of soluble fibrinomonomer complexes, this indicating a lowering of the blood coagulation potential. Absence of significant changes in plasminogen level may be an indicator of the nonenzymic route of fibrinogen system activation. Sessions of intravenous laser therapy should be administered 2-3 times a week to unstable angina pectoris patients with low AT-III levels, whereas for patients with initially high or normal AT-III levels combined laser therapy is advisable (4-5 daily invasive procedures and 6-8 skin surface ones on the Zakharyin-Head's zones). Measurements of endogenic anticoagulants is an effective means for monitoring laser therapy in this patient population.
Vestn Khir Im I I Grek. 2000;159(2):60-4.

The Effect Of Different Methods Of Photohemotherapy On The Rheological
Properties Of The Blood In Patients With Ischemic Heart Disease
Gavrisheva IA, Dutkevich IG, Pleshakov VT, Kolesnik VS.- Article in Russian
The authors made an analysis of results of examination of 41 patients with ischemic heart disease treated by the standard medicamentous therapy and when using different methods of photohemotherapy against its background. It was established that medicamentous therapy during 2 weeks failed to result in a substantial improvement of rheological properties of blood, while its combination with photohemotherapy could give a considerable positive effect coinciding with clinical improvement of the patient's state. Shorter terms are required to correct hemorheological indices when autotransfusions of photomodified blood are used.