Laser therapy research, LLLT investigations and studies

Atsumi K et al. Biostimulation effect of low-power energy diode laser for pain relief.
Lasers Surg Med. 1987; 7: 77.

Barabas K et al. Controlled clinical and experimental examinations on rheumatoid arthritis patients and synovial membranes performed with neodym phosphate glas laser irradiation. Proc. 7th Congr Internat Soc for Laser Surg and Med, Munich June 1987. Abstract no 216a.

Boerner E et al. Double-blind study on the efficacy of the lasertherapy. SPIE Proc. 1996. Vol. 2929: 75-79.
Cheng R. Combined treatments of electrotherapy plus soft laser therapy has synergistic effect in pain relief and disease healing. Surgical and Medical Lasers. 1990; 3 (3): 135

Cieslar G et al. Effect of low-power laser radiation in the treatment of the motional system overloading syndromes. SPIE Proc. Vol 3198. 1997, pp. 76-82.

Emmanoulidis O et al. CW IR low-power laser application significantly accelerates chronic pain relief rehabilitation of professional athletes. A double blind study. Lasers Surg Med. 1986; 6: 173.
Haruki E, Yamaguchi S. Double blind evaluation of low energy laser treatment for painful disease. J Phys Med. 1995; 6: 60-67. (In Japanese with English abstract)

Hopkins G O et al. Double blind cross over study of laser versus placebo in the treatment of tennis elbow. Proc Internat Congr on Lasers, „Laser Bologna“. 1985: 210. Monduzzi Editore S.p.A., Bologna.
Hoshino H et al. The effect of low reactive level laser therapy in the field of orthopedic surgery. Chronic Pain. 1994; 13: 101-109. (In Japanese with English abstract)

Hoteya K et al. Effects of a 1 W GaAlAs diode laser in the field of orthopedics. In: Meeting Report: The first Congress of the International Association for Laser and Sports Medicine. Tokyo, 1997. Laser Therapy 1997; 9 (4): 185.

Kamikawa K et al. Double blind experiences with mid-Lasers in Japan. 1985. Proc. Int. Congr. on Lasers, „Laser Bologna“. 1985.

Kim J W, Lee J O. Double blind cross-over clinical study of 830 nm diode laser and 5 years clinical experience of biostimulation in plastic & aesthetic surgery in Asians. Lasers Surg Med. 1998; Suppl. 10: 59.

Kinoshita F et al. Clinical evaluation of low-energy, semi-conductor laser therapy in oral surgery - a double blind study. Josai Shika Daigaku Kiyo (Bulletin of Josai Dental University). 1986; 15 (3): 735-742. (in Japanese with English abstract)

Kosaka R et al. Double blind study of low energy diode laser irradiation for chronic pain disorders. J Phys Med. 1993; 4: 156-160.

Kouno A et al. The evaluation of pain therapy with low powerlaser- Comparative study of thermography and double blind test. Biomedical Thermology. 1993; 13: 102-107.

Lonauer G: Controlled double blind study on the efficacy of HeNe-laser beams versus HeNe- plus Infrared-laser beams in the therapy of activated osteoarthritis of finger joints. Clin Experim Rheuma. 1987; 5
(suppl 2) : 39

Lucas C et al. Low level laser therapy bij decubitus statium III. Rapport Hoegschool van Amsterdam. 1994.
Mach E S et al. Helium-Neon (Red Light) Therapy of Arthritis. Rhevmatologia, 1983; 3: 36. (In Russian)
Mester A: Biostimulative effect in wound healing by continous wave 820 nm laser diode. Double-blind randomized cross-over study. Lasers in Med Science, abstract issue July 1988, No 289.

Miyagi K. Double-blind comparative study of the effect of low-energy laser irradiation to rheumatoid arthritis. In: Current awareness of Excerpts Medica. Amsterdam. Elsevier Science Publishers BV. 1989; 25: 315.

Mokhtar B et al. A double blind placebo controlled investigation of the hypoalgesic effects of low intensity laser irradiation of the cervical roots using experimental ischaemic pain. Proc. Second Meeting of the International Laser Therapy Assn., „London Laser“, Sept 1992, p 61. Mokhtar B et al. The possible significance of pulse repetition rate in lasermediated analgesia: A double blind placebo controlled investigation using experimental ischaemic pain. Proc. Second Meeting of the International Laser Therapy Assn, „London Laser“ Sept 1992. p 62

Neuman I et al. Low energy phototherapy in allergic rhinitis and nasal polyposis. Laser Therapy. 1996. 1: 37.

Palmgren N et al. Low Level Laser Therapy of infected abdominal wounds after surgery. Lasers Surg Med. 1991; Suppl 3:11.

Poliakova A G., Gladkova N D, Triphonova T.D. Laserpuncture in patients with rheumatoids arthritis. Abstracts of ICMART ’97 International Medical Acupuncture Symposium, Nicosia, Cyrprus, March 26-29 1997.

Rochkind S et al. Double-blind Randomized Study Using Neurotube and Laser Therapy in the Treatment of Complete Sciatic Nerve Injury of Rats. Proc. 2nd Congr World Assoc. for Laser Therapy, Kansas City, 1998.

Roumeliotis D et al. 820nm 15mW 4J/cm2, laser diode application in sports injuries. A double blind study. Proc. Fifth Annual Congress British Medical Laser Ass. 1987.

Ryo E et al. Double blind test of low energy laser radiation treatment. Evaluation of effectiveness for shoulder stiffness, arthralgia etc. Pain Clinic. 1986; 7: 185-192. (In Japanese with English abstract)
Saeki N et al. Double blind test for biostimulation effects on pain releif by diode laser. 1989. Laser Surgery; 1066: 93-100.

Sasaki K et al. A double-blind controlled study on free amino acid analysis in CO2 laser burn wounds in the mouse model following doses of low incident infrared (830 nm) diode laser energy. Proc. 2nd Meeting if the Internat Laser Therapy Assn., London, 1992, p.4.

Sato K et al. A double blind assessment of low power laser therapy in the treatment of postherpetic neuralgia. Surgical and Medical Lasers. 1990; 3 (3): 134.

Scudds R A et al. A double-blind crossover study of the effects of low-power gallium arsenide laser on the symptoms of fibrositis. Physiotherapy Canada.1989; 41: (suppl 3): 2.

Taghawinejag M et al. Laser-Therapie in der Behandlung kleiner Gelenke bei chronischer Polyarthritis. Z Phys Med Baln Med Klin. 1985; 14.

Tsurko V V et al. Laser therapy of rheumatoid arthritis. A clinical and morphological study. Ter Arkh. 1983; 55 (7) 97-102. (Russian).

Umegaki S et al. Effectiveness of low-power laser therapy on low back pain. Double blind comparative study to evaluate the analgesic effect of low power laser therapy on low-back pain. The Clinical Report. 1989; 23: 2839-2846. (Japanese, English abstract)

Vélez-Gonzalez M et al. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and „area pudenda“ with low power HeNe-laser or Acyclovir administred orally. SPIE Proc. 1995; Vol. 2630: 43-50

Willner R et al. Low power infrared laser biostimulation of chronic osteoarthritis in hand. Lasers Surg Med. 1985; 5: 149.

Wylie L et al. The hypoalgesic effects of low intensity infrared laser therapy upon mechanical pain threshold. Lasers Surg Med. 1995; Suppl 7: 9.

Yamaguchi M et al. Clinical study on the treatment of hypersensitive dentine by GaAlAs laser diode using the double blind test. Aichi Gakuin Daigaku Shigakkai Shi - Aichi-Gakuin Journal of Dental Science. 1990; 28( 2): 703-707. (in Japanese)

Yoh K et al. A clinical trial for treatment of chronic pain in orthopedic diseases by using 150 mW diode laser system. Result of double blind test. Chronic Pain; 13: 96-100.(In Japanese with English abstract)

Kim J W, Lee J O. Double blind cross-over clinical study of 830 nm diode laser and 5 years clinical experience of biostimulation in plastic & aesthetic surgery in Asians. Lasers Surg Med. 1998; Suppl. 10: 59.

Kinoshita F et al. Clinical evaluation of low-energy, semi-conductor laser therapy in oral surgery - a double
blind study. Josai Shika Daigaku Kiyo (Bulletin of Josai Dental University). 1986; 15 (3): 735-742. (in Japanese with English abstract)

Kosaka R et al. Double blind study of low energy diode laser irradiation for chronic pain disorders. J Phys Med. 1993; 4: 156-160.

Kouno A et al. The evaluation of pain therapy with low powerlaser- Comparative study of thermography and double blind test. Biomedical Thermology. 1993; 13: 102-107.

Lonauer G: Controlled double blind study on the efficacy of HeNe-laser beams versus HeNe- plus Infrared-laser beams in the therapy of activated osteoarthritis of finger joints. Clin Experim Rheuma. 1987; 5 (suppl 2) : 39

Lucas C et al. Low level laser therapy bij decubitus statium III. Rapport Hoegschool van Amsterdam. 1994.

Mach E S et al. Helium-Neon (Red Light) Therapy of Arthritis. Rhevmatologia, 1983; 3: 36. (In Russian)

Mester A: Biostimulative effect in wound healing by continous wave 820 nm laser diode. Double-blind randomized cross-over study. Lasers in Med Science, abstract issue July 1988, No 289.

Miyagi K. Double-blind comparative study of the effect of low-energy laser irradiation to rheumatoid arthritis. In: Current awareness of Excerpts Medica. Amsterdam. Elsevier Science Publishers BV. 1989; 25: 315.

Mokhtar B et al. A double blind placebo controlled investigation of the hypoalgesic effects of low intensity laser irradiation of the cervical roots using experimental ischaemic pain. Proc. Second Meeting of the International Laser Therapy Assn., „London Laser“, Sept 1992, p 61. Mokhtar B et al. The possible significance of pulse repetition rate in lasermediated analgesia: A double blind placebo controlled investigation using experimental ischaemic pain. Proc. Second Meeting of the International Laser Therapy Assn, „London Laser“ Sept 1992. p 62

Neuman I et al. Low energy phototherapy in allergic rhinitis and nasal polyposis. Laser Therapy. 1996. 1: 37.

Palmgren N et al. Low Level Laser Therapy of infected abdominal wounds after surgery. Lasers Surg Med. 1991; Suppl 3:11.

Poliakova A G., Gladkova N D, Triphonova T.D. Laserpuncture in patients with rheumatoids arthritis.
Abstracts of ICMART ’97 International Medical Acupuncture Symposium, Nicosia, Cyrprus, March 26-29 1997.

Rochkind S et al. Double-blind Randomized Study Using Neurotube and Laser Therapy in the Treatment of Complete Sciatic Nerve Injury of Rats. Proc. 2nd Congr World Assoc. for Laser Therapy, Kansas City, 1998.

Roumeliotis D et al. 820nm 15mW 4J/cm2, laser diode application in sports injuries. A double blind study. Proc. Fifth Annual Congress British Medical Laser Ass. 1987.

Ryo E et al. Double blind test of low energy laser radiation treatment. Evaluation of effectiveness for shoulder stiffness, arthralgia etc. Pain Clinic. 1986; 7: 185-192. (In Japanese with English abstract)

Saeki N et al. Double blind test for biostimulation effects on pain releif by diode laser. 1989. Laser Surgery; 1066: 93-100.

Sasaki K et al. A double-blind controlled study on free amino acid analysis in CO2 laser burn wounds in the mouse model following doses of low incident infrared (830 nm) diode laser energy. Proc. 2nd Meeting if the
Internat Laser Therapy Assn., London, 1992, p.4.

Sato K et al. A double blind assessment of low power laser therapy in the treatment of postherpetic neuralgia. Surgical and Medical Lasers. 1990; 3 (3): 134.

Scudds R A et al. A double-blind crossover study of the effects of low-power gallium arsenide laser on the symptoms of fibrositis. Physiotherapy Canada.1989; 41: (suppl 3): 2.

Taghawinejag M et al. Laser-Therapie in der Behandlung kleiner Gelenke bei chronischer Polyarthritis. Z Phys Med Baln Med Klin. 1985; 14.

Tsurko V V et al. Laser therapy of rheumatoid arthritis. A clinical and morphological study. Ter Arkh. 1983; 55 (7) 97-102. (Russian).

Umegaki S et al. Effectiveness of low-power laser therapy on low back pain. Double blind comparative study to evaluate the analgesic effect of low power laser therapy on low-back pain. The Clinical Report. 1989; 23: 2839-2846. (Japanese, English abstract)

Vélez-Gonzalez M et al. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and „area pudenda“ with low power HeNe-laser or Acyclovir administred orally. SPIE Proc. 1995; Vol. 2630: 43-50

Willner R et al. Low power infrared laser biostimulation of chronic osteoarthritis in hand. Lasers Surg Med. 1985; 5: 149.

Wylie L et al. The hypoalgesic effects of low intensity infrared laser therapy upon mechanical pain threshold. Lasers Surg Med. 1995; Suppl 7: 9.

Yamaguchi M et al. Clinical study on the treatment of hypersensitive dentine by GaAlAs laser diode using the double blind test. Aichi Gakuin Daigaku Shigakkai Shi - Aichi-Gakuin Journal of Dental Science. 1990; 28( 2): 703-707. (in Japanese)

Yoh K et al. A clinical trial for treatment of chronic pain in orthopedic diseases by using 150 mW diode laser system. Result of double blind test. Chronic Pain; 13: 96-100.(In Japanese with English abstract)

Neuman I et al. Low energy phototherapy in allergic rhinitis and nasal polyposis. Laser Therapy. 1996. 1: 37.

Palmgren N et al. Low Level Laser Therapy of infected abdominal wounds after surgery. Lasers Surg Med. 1991; Suppl 3:11.

Poliakova A G., Gladkova N D, Triphonova T.D. Laserpuncture in patients with rheumatoids arthritis. Abstracts of ICMART ’97 International Medical Acupuncture Symposium, Nicosia, Cyrprus, March 26-29 1997.

Rochkind S et al. Double-blind Randomized Study Using Neurotube and Laser Therapy in the Treatment of Complete Sciatic Nerve Injury of Rats. Proc. 2nd Congr World Assoc. for Laser Therapy, Kansas City, 1998.

Roumeliotis D et al. 820nm 15mW 4J/cm2, laser diode application in sports injuries. A double blind study. Proc. Fifth Annual Congress British Medical Laser Ass. 1987.

Ryo E et al. Double blind test of low energy laser radiation treatment. Evaluation of effectiveness for shoulder stiffness, arthralgia etc. Pain Clinic. 1986; 7: 185-192. (In Japanese with English abstract)

Saeki N et al. Double blind test for biostimulation effects on pain releif by diode laser. 1989. Laser Surgery; 1066: 93-100.

Sasaki K et al. A double-blind controlled study on free amino acid analysis in CO2 laser burn wounds in the mouse model following doses of low incident infrared (830 nm) diode laser energy. Proc. 2nd Meeting if the Internat Laser Therapy Assn., London, 1992, p.4.

Sato K et al. A double blind assessment of low power laser therapy in the treatment of postherpetic neuralgia. Surgical and Medical Lasers. 1990; 3 (3): 134.

Scudds R A et al. A double-blind crossover study of the effects of low-power gallium arsenide laser on the symptoms of fibrositis. Physiotherapy Canada.1989; 41: (suppl 3): 2.

Taghawinejag M et al. Laser-Therapie in der Behandlung kleiner Gelenke bei chronischer Polyarthritis. Z Phys Med Baln Med Klin. 1985; 14.

Tsurko V V et al. Laser therapy of rheumatoid arthritis. A clinical and morphological study. Ter Arkh. 1983; 55 (7) 97-102. (Russian).

Umegaki S et al. Effectiveness of low-power laser therapy on low back pain. Double blind comparative study to evaluate the analgesic effect of low power laser therapy on low-back pain. The Clinical Report. 1989; 23: 2839-2846. (Japanese, English abstract)

Vélez-Gonzalez M et al. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and „area pudenda“ with low power HeNe-laser or Acyclovir administred orally. SPIE Proc. 1995; Vol. 2630: 43-50

Willner R et al. Low power infrared laser biostimulation of chronic osteoarthritis in hand. Lasers Surg Med. 1985; 5: 149.

Wylie L et al. The hypoalgesic effects of low intensity infrared laser therapy upon mechanical pain threshold. Lasers Surg Med. 1995; Suppl 7: 9.

Yamaguchi M et al. Clinical study on the treatment of hypersensitive dentine by GaAlAs laser diode using the double blind test. Aichi Gakuin Daigaku Shigakkai Shi - Aichi-Gakuin Journal of Dental Science. 1990; 28( 2): 703-707. (in Japanese)

Yoh K et al. A clinical trial for treatment of chronic pain in orthopedic diseases by using 150 mW diode laser system. Result of double blind test. Chronic Pain; 13: 96-100.(In Japanese with English abstract)

Human gingival fibroblast proliferation enhanced by LLLT
Almeida-Lopes L. [Analysis in vitro of the cellular proliferation of human gingival fibroblasts with low level laser.] 1999. Dissertation at Universidade do Vale do Paraíba, São Paulo, Brazil.

PhD dissertation on TMD problems

Dr Sajee Sattayut of The Department of Oral & Maxillofacial Surgery, St Bartholomew’s and the Royal London School of Medicine and Dentistry (professor Paul Bradley) has put forward his PhD thesis on the effect of 820 nm low level laser on patients with TMD (temporo-mandibular-joint-disorders.

Other recent dissertations:
Luciana Almeida-Lopes DDS, Universidade do Vale do Paraíba, São José dos Campos, Sao Paulo. Análise in vitro da proliferação celular de fibroblastos de gengiva humana tratados com laser de baixa potencia.

Julia Kenter DDS, Dental faculty of the UNI Aachen, Germany. Die Anwendung des low-level-laser in der Human, Dental- & Vet.medizin.

Navtrátil L, Navtrátilová B. Possibilities of the treatment of certain diseases in stomatology with the help of non-invasive laser therpay.
382 dental patients were evaluated.

Passeniouk A M, Michailov V A. A comparison between laser therapy and drug therapy in the treatment of vaginitis 30 women with non-specific vaginitis and vaginal candidiasis were treated with LLLT and topical chlorhexidine application daily for ten days. 20 women with the same condition were treated with metronidazole (10 g as course dose) and fluconozole (150 mg single dose) and vaginal application of metronidazole.

Ailioaie C, Ailioaie L. The treatment of bronchial asthma with LLLT in attack-free period in children.
98 patient aged 10-18 years, diagnosed with moderate or severe asthma were divided into three groups.

Simunovic Z, Ivankovich A D, Depolo A. Wound healing on animal and human body with use of low level laser therapy - treatment of operated sport and traffic accident injuries: a randomized clinical study on 74 patients with control group. A wound healing study on rabbits suggested that 4 J/cm2 was the optimal dose. A clinical study was performed on 74 patients suffering from injuries of soft tissue upon traffic accidents and sport activities. Schaffer M et al. Effects of 780 nm diode laser irradiation on blood microcirculation - study by time dependent T1-wieghted enhanced magnetic resonance imaging (MRI).
Six healthy volounteers were irradiated on their right pianta pedis with 5J/cm2 and a fluence rate of 100 mW/cm2.

Schaffer M et al. Magnetic resonance imaging (MRI) controlled outcome of ionizing radiation side effects treated with 780 nm diode laser, preliminary results.
Three women with painful mastitis after breast ionizing irradiation and a man with an ionizing ulcer were treated with 780 nm, 5 J/cm2.

Bjordal J M. Low level laser therapy can be effective for tendinitis: a meta-analysis.
A literature search identified 77 randomized clinical trials with LLLT, of which 18 included tendinitis.

Prochazka M, Tejnska R. Comprehensive therapy of patients suffering from tinnitus.
37 patients suffering from tinnitus (age 18-86 years) were treated in three ways: 1. Rehabilitation: mobilisation, physical training, physiotherapy. 2. Same as 1 but with placebo laser added. 3. Same as 1 but with functional laser added. Laser used was 830 nm 300 mW.

Beyer W et al. Light dosimetry and preliminary clinical results for low level laser therapy in cochlear dysfunction.
The light distribution inside the cochlear windings produced by irradiation of the tympanic membrane was quantitatively measured ex vivo for wavelengths of 593, 612, 635, 690, 780 and 805 nm.

Schindl A, Neuman R. Low-intensity laser therapy is an effective treatment for recurrent herpes simplex infection. Results from a randomized double-blind placebo controlled study.
J Investigative Dermatology. 1999; 113 (2): 221-223.
50 patients with recurrent perioral herpes simplex infections (at least once a month for more than 6 months) were treated with 690 nm, 80 mW laser, 48 J/cm2, in a double blind study.

Review article: Marks R, de Palma F. Clinical efficacy of low power laser therapy in osteoarthritis.
Physiotherapy Research International. 1999; 4 (2): 141-57.

A pilot study used six Sprague-Dawley rats - three controls with no treatment and three that were irradiated for 250 seconds with 630 nm.

The interauricular laser therapy of rheumatoid arthritis). Interaurikuliarnaia lazernaia terapiia revmatoidnogo artrita. Sidorov-V-D, Mamiliaeva-D-R, Gontar-E-V, Reformatskaia-SIu.
Vopr-Kurortol-Fizioter-Lech-Fiz-Kult. 1999; (3): 35-43.
Investigations have proved the ability of interauricular low- intensity infrared laser therapy (0.89 nm, 7.6 J/cm) to produce anti- inflammatory, immunomodulating action in patients with rheumatoid arthritis.

Low-intensity laser therapy for benign fibrotic lumps in the breast following reduction mammaplasty. Nussbaum-E-L.

Physical Therapy. 1999; 79 (7): 691-698.
Fibrotic masses in the breast secondary to fat necrosis or hematoma are a complication of breast reduction mammaplasty. The treatment commonly recommended for this condition is early surgical debridement of necrotic tissue from the entire area, which causes scarring. The patient had some tissue thickening at the time of discharge after 6 months of treatment.

Laser therapy: a randomized, controlled trial of the effects of low-intensity Nd:YAG laser irradiation on musculoskeletal back pain. Basford-J-R, Sheffield-C-G, Harmsen-W-S

Arch-Phys-Med-Rehabil. 1999; 80 (6): 647-52
This study was assessed to investigate the effectiveness of low-intensity Nd:YAG laser therapy in the treatment of musculoskeletal low back pain as a double-masked, placebo-controlled, randomized clinical trial. 63 ambulatory men and women between the ages of 18 and 70 years with symptomatic nonradiating low back pain of more than 30 days’ duration.

Laser’s effect on bone and cartilage change induced by joint immobilization: an experiment with animal model. Akai M, Usuba M, Maeshima T, Shirasaki Y, Yasuoka S.

Lasers Surg Med. 1997. 21(5): 480-4.
The influence of low-level (810 nm)) laser on bone and cartilage during joint immobilization was examined with rats’ knee model.

Clinical results evaluation of dentinary hypersensitivity patients treated with laser therapy.
Brugnera A, Cruz FM, Zanin FA & Pecora Jd.

Proc. SPIE Vol. 3593, 1999, p. 66-68.
300 human teeth were treated for hypersensitivity during the period 1995-1997. Pulpal vitality was verified using thermal tests, and only reversible processes were treated.
Stimulatory effect of 660 nm low level laser energy on hypertrophic scar-derived fibroblasts: possible mechanisms for increase in cell counts. Webb C, Dyson M, Lewis WH.

Lasers Surg Med. 1998; 22(5):294-301.
The experiments investigated the effect of a 660 nm, 17 mW laser diode at dosages of 2.4 J/cm2 and 4 J/cm2 on cell counts of two human fibroblast cell lines, derived from hypertrophic scar tissue and normal dermal tissue explants.