Angiogenesis |
Mirsky N, Krispel Y, Shoshany Y, Maltz L,
Oron U.
Promotion of angiogenesis by
low energy laser irradiation.
Antioxid Redox Signal. 2002; 4 (5):
785-790.
The effect of HeNe
irradiation on the process of angiogenesis in the
infarcted rat heart and in the chick chorioallantoic
membrane (CAM), as well as the proliferation of
endothelial cells in tissue culture, was investigated by
Mirsky. Formation of new blood vessels in the infarcted
rat heart was monitored by counting proliferating
endothelial cells in blood vessels. In the CAM model,
defined areas were laser-irradiated or non-irradiated
and blood vessel density was recorded in each site in
the CAM at various time intervals. Laser irradiation
caused a 3.1-fold significant increase in newly formed
blood vessels 6 days post infarction, as compared with
non-irradiated rats. In the CAM model, a slight
inhibition of angiogenesis up to 2 days post irradiation
and a significant enhancement of angiogenesis in the
laser-irradiated foci as compared with control
non-irradiated spots were evident. The laser irradiation
caused a 1.8-fold significant increase in the rate of
proliferation in endothelial cells in culture over
non-irradiated cells.
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